English, J.C. and Deisinger, P.J. Place water in container then bring the temperature to 15c in a boil bath then add products at this point when youre making the lotion u will need to add the other ingredients. J. LSPS, Laboratoire de Spectrochimie Et Pharmacologie Structurale, University of Tlemcen, BP 119, 13000, Tlemcen, Algeria, Department of Biology, University of Ghardaia, BP 455, 47000, Ghardaia, Algeria, You can also search for this author in As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. 4. Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. ChemPoint will not under any circumstances release personal user information to individuals or companies. International Journal of Thermophysics . Hydroquinone (C 6 H 4 (OH) 2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. Thermodyn. The Density of hydroquinone is . The disodium diphenolate salt of hydroquinone is used as an alternating comonomer unit in the production of the polymer PEEK. I'd like the consistency to be thin like a gel so that it absorbs quicker. Hydroquinone (C6H4(OH)2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. Mobility in soil No additional information available 12.5. Determination and Correlation of Solubilities of Benzoic Acid, Salicylic Acid, Resorcinol and Hydroquinone in Water and in 1-Octanol at Temperatures from 297.25K to 334.45K. Some documentation and label information may refer to the legacy brand. The Molecular Weight is 110.11 g/mol. Hydroquinone is used as a topical application in skin whitening to reduce the color of skin. It is a major component in most black and white photographic developers for film and paper where, with the compound metol, it reduces silver halides to elemental silver. This is seen at about a pH of 3.50 with at least about 2.0% magnesium ascorbyl phosphate, and again at a pH of about 6.5 to about 7.0 with at least about 2.0% magnesium ascorbyl phosphate. A2, Designated state(s): Eng. [19][20], In 2006, the United States Food and Drug Administration revoked its previous approval of hydroquinone and proposed a ban on all over-the-counter preparations. It can also be found on eBay and Amazon. Protected retinoid may be added to these compositions for additional skin benefit effects. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. 38, 565571 (2006), K. Carlsson, B. Karlberg, Anal. Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. Using a laser-monitoring observation technique, the solubility of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid were measured at temperatures ranging from 276.65 K to 345.10 K under the atmospheric pressure. You can expect to hear back from a ChemPoint product specialist within 1 business hour. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. Other adverse effects STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN. In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. [21] The FDA officially banned hydroquinone in 2020 as part of a larger reform of the over-the-counter drug review process. So, does anybody know of another solvent I could use that has a higher solubility and is relatively non-toxic. Data 53, 12781282 (2008), A. It is also used to prepare 2% bleaching creams and certain intermediates for the synthesis of dyes, and it has some activity as an antitumoragent. Recent pieces of . Obagi Nu-Derm Clear (Hydroquinone USP, 4%) Skin Bleaching Cream Obagi You take the cream, put it in a container, take the powder measurement and add it. The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Belhachemi, B., Makhlouf, H. & Belhachemi, M.H. [17], An important reaction is the conversion of hydroquinone to the mono- and diamine derivatives. HMkA+"c>jZ^ho=81NW;]Ib;+i#iFArHpz). `9F6~qg3]0,#!V9Q> p=|h| 1401417, Country of ref document: Data 51, 127129 (2006), J. Lim, S. Jang, H. K. Cho, M. S. Shin, H. Kim, J. Chem. Bioaccumulative potential Hydroquinone (123 -31 -9) Bioaccumulative potential Not established. The obtained results show that the . Substituted derivatives of this parent compound are also referred to as hydroquinones. Such carriers are widely known in the art and deliver the composition's ingredients to the skin without excessive degradation, inactivation or other unwanted interaction. 88, 161164 (2010), J. Delgado, Int. EP, Kind code of ref document: Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. Heat Mass Transf. All Rights Reserved, View All Eastman Hydroquinone USP Articles. Preparation, optimization and in vivo. Dietland Muller-Schwarze, 2003, page 43 (, National Institute for Occupational Safety and Health, Additive manufacturing of ceramics from preceramic polymers, http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31976L0768:EN:HTML, "Clear N Smooth Skin Toning Cream recalled", Skin Bleaching Drug Products for Over-the-Counter Product Use; Proposed Rule, "About the Center for Drug Evaluation and Research - Hydroquinone Studies Under The National Toxicology Program (NTP)", Campaign For Safe Cosmetics - Hydroquinone, "Skin lightening preparations and the hydroquinone controversy", https://en.wikipedia.org/w/index.php?title=Hydroquinone&oldid=1136453324, Wikipedia articles needing page number citations from October 2016, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, The most widely used route is similar to the, A potentially significant synthesis of hydroquinone from, Hydroquinone was first obtained in 1820 by the French chemists, Pelletier and Caventou (1820) "Recherches chimiques sur les quinquinas" (Chemical investigations of quinquinas [i.e., the bark of various, This page was last edited on 30 January 2023, at 11:09. - 65.21.225.73. Do not put this product in the microwave. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. Hydroquinone - Wikipedia 2017-02-16T10:10:56+01:00 Lastly, I'd like to add benzoic acid for preservation purposes. 0000053439 00000 n 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. Hydroquinone Safety Data Sheet according to Federal Register / Vol. 20grams ofhydroquinonein 20oz is liquid is 10%. For more information, please see our Also in this embodiment is a cationic salt of acidic ascorbyl esters, which further helps to maintain the acceptable color desired in the hydroquinone composition. The drug is freely soluble in water and in alcohol. HYDROQUINONE (hahy droh kwi NOHN) is applied to the the skin to lighten areas that have darkened. Find answers in our support articles. S.C. Gad, T. Pham, in Encyclopedia of Toxicology (Third Edition), 2014 Environmental Fate and Behavior. At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. Table I shows that at 5C, 4% hydroquinone compositions maintain their white color with the addition of at least about 0.01% sodium metabisulfite at the low pH ranges (from about 3.50 to about 5.50) and at least 0.05% sodium metabisulfite for pH about 6.0 to about 7.0. It is a reducing agent that is reversibly oxidized to semiquinone and quinone. 552591, Z. Esina, M. Korchuganova, Theor. Preferably, the protected retinoid, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), is in the form of small beads or spheres suitable for incorporation into a topical composition. . [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. Chem. For use herein, the encapsulation forms a protective system to prohibit or inhibit the oxidation of the retinoid. Eng. Cite this article. 15, 188196 (1996), U. Domaska, Fluid Phase Equilib. 338, 217223 (2013), S. H. Ali, F. S. Al-Mutairi, M. A. Fahim, Fluid Phase Equilib. It is moderately soluble in water and highly soluble in alcohol. The combined nearly ideal binary solvent (NIBS)-Redlich-Kister equation is . The FDA had classified hydroquinone in 1982 as a safe product - generally recognized as safe and effective (GRASE), however additional studies under the National Toxicology Program (NTP) were suggested in order to determine whether there is a risk to humans from the use of hydroquinone. Chem. One skilled in the art is familiar with the known protective system technologies, such as encapsulation and entrapment methodologies. ~lgM~Gc{1S_1Q/_/v">S 9 Ferulic acid 0.5% 0.15g. D7VJV//KZ&t}JSW/L@,l@^ D@ @8 i W `^;V rD}25p>.Bv1}\_E p9 endstream endobj 392 0 obj 1303 endobj 376 0 obj << /Type /Page /Parent 350 0 R /Resources 377 0 R /Contents 381 0 R /MediaBox [ 0 0 595 842 ] /CropBox [ 0 0 595 842 ] /Rotate 0 >> endobj 377 0 obj << /ProcSet [ /PDF /Text ] /Font << /TT2 379 0 R /TT4 383 0 R /TT6 385 0 R >> /ExtGState << /GS1 387 0 R >> /ColorSpace << /Cs6 378 0 R >> >> endobj 378 0 obj [ /ICCBased 386 0 R ] endobj 379 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 252 /Widths [ 250 0 408 500 0 833 778 180 333 333 500 564 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 564 564 564 444 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 611 333 0 333 0 500 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 333 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 400 0 0 0 0 576 0 0 0 0 0 0 0 750 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 722 0 0 0 0 0 722 0 0 500 444 0 0 0 444 0 0 0 444 444 0 0 0 0 0 0 0 0 0 0 500 0 500 0 0 0 0 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /BCGIOE+TimesNewRoman /FontDescriptor 380 0 R >> endobj 380 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /BCGIOE+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 388 0 R >> endobj 381 0 obj << /Length 462 /Filter /FlateDecode >> stream Thanks to the added vitamin E, it leaves your skin feeling smooth and soft, too. We will respond to you shortly. It is not to be considered as either a warranty or quality specification. When the contents of the reservoir are forced into the reaction chamber, the catalases and peroxidases rapidly break down the hydrogen peroxide and catalyze the oxidation of the hydroquinones into p-quinones. One embodiment of the invention is a composition which comprises hydroquinone (about 1% to about 12%, preferably about 2% to about 10%, more preferably about 2% to about 8%, more preferably with about 2% to about 4%, and most preferably about 3% to about 4%) and has a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. 0000003660 00000 n There are various other uses associated with its reducing power. Environ. Forms of retinoids have been developed wherein the retinoid is protected by a protective system. Hydroquinone compositions are effective but have some undesirable side effects. The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. Compositions according to this invention may include additives or components to enhance the skin penetration of its ingredients. application/pdf PDF Hydroquinone Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. :hS-g"s2Sj Ij=x'V]gPV8tt~qkAVXi|u}5;#.pl-/4JFQ.EP3&F.qa2hI{N qBmG(z#n [GN.}aazN(~8kux9#tnYwIHFuxW v9UNj&ffNW_\\Tc""8=_"7wC>svwQy\^4gF H][QzmlOI(B@ U4[Xb0,|m0*D"/#$\u(QI)RYg\;8 Yjh Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Hi, let us know if you have any questions as you visit our website. As a polymerisation inhibitor, exploiting its antioxidant properties, hydroquinone prevents polymerization of acrylic acid, methyl methacrylate, cyanoacrylate, and other monomers that are susceptible to radical-initiated polymerization. 374 0 obj << /Linearized 1 /O 376 /H [ 807 1414 ] /L 581425 /E 96582 /N 109 /T 573826 >> endobj xref 374 19 0000000016 00000 n However, these hydroquinone-containing compositions were in the acidic pH range and did not contain cationic salts of acidic ascorbyl esters, such as magnesium ascorbyl phosphate. Hydroquinone is considered to be readily biodegrable and photodegradable. 0000005757 00000 n Hydroquinone, like phenols are very weak acids and can be deprotonated. Fill out the form below, and we will send you the document as soon as we can! Other solubilities: soluble in alcohol and ether,slightly soluble in benzene,readily soluble in ethanol,acetone and methanol, Needle-like Crystals or Crystalline Powder. A further embodiment of the invention includes a method for stabilizing a hydroquinone composition (with about 1% to about 12% hydroquinone, preferably about 2% to about 10%, more preferably about 2% to about 8%, and most preferably about 3% to about 4%) with a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, by adding a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate. Calorim. This complex dissolves in hot water, where the two molecules dissociate in solution. Please sign in to view account pricing and product availability. Hydroquinone is combustible when preheated. J. Pharm. The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. SOLUBILITIES - DrugFuture [32], Hydroquinone is thought to be the active toxin in Agaricus hondensis mushrooms. It is soluble in water. The information given is designed only as a guide for safe handling and use. Protected retinoid, with its skin benefit capabilities, may also be included with the hydroquinone composition. 2017-02-16T10:10:56+01:00 This range of pH has been preferred for hydroquinone compositions, because it has been believed that the hydroquinone is less likely to excessively discolor under acid conditions. nQt}MA0alSx k&^>0|>_',G! I would like to add retinol and kojic acid to it as well. Hydroquinone is combustible when preheated. 2008-2023 ChemPoint. Stabilisation of biofuels with hydrophilic, natural antioxidants 0000002585 00000 n Hydroquinone USP, Eastman - ChemPoint Approved only for prescription use in the U.S. market.Ideal for creams, lotions, and gels for personal care ingredients, pharmaceutical chemical, pharmaceutical excipients, and skin care ingredients. The solubility in water is 6.72g/L. The obtained results show that the solubility of benzoic acid in water is greater than that of salicylic acid, but in the case of the two isomers of dihydroxybenzene, the solubility of resorcinol is approximately 100 times that of hydroquinone. 12.4. Availability. Can be destroyed by oxidizing it with an oxidizing mixture. If you are already a ChemPoint customer then sign up for access to our online ordering website. Reddit and its partners use cookies and similar technologies to provide you with a better experience. 322, 4855 (2012), K. Tamura, T. Kasuga, T. Nakagawa, Fluid Phase Equilib. Hydroquinone is a white, odorless, crystalline solid with an extremely low vapor pressure. Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. Editor's Rating: Azelaic acid (AzA) is a organic compound with the formula HOOC(CH 2) 7 COOH. 76/768/EEC:1976 Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products: Organic Chemistry, Solomon and Fryhle, 10th edition, Wiley Publishing, 2010. This is a prescription-only ingredient in some countries, including the member states of the European Union under Directives 76/768/EEC:1976. The present invention combats this problem, with hydroquinone compositions in the neutral pH range, preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Johnson & Johnson Consumer Products, Inc. Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions. Eastman Hydroquinone, USP Grade is for skin-lightening products to address hyperpigmentation. 2023 Springer Nature Switzerland AG. The document was not able to download due to an unknown error. Hydroquinone is combustible when preheated. Monobenzone: Uses, Interactions, Mechanism of Action - DrugBank We have found that a cream containing 5% of hydroquinone and 0.05 % of laevo-ascorbic acid remains white, and the emulsion remains unbroken after many months of storage, The laevo-ascorbic or cevitamic acid is pr'eferably employed in the free condition; but if desired, the salts, and especially the water-soluble salts thereof, may be employed . Formula of hydroquinone is . hydroquinone, 1,4-benzenediol, quinol, 1,4-dihydroxybenzene, p-benzenediol, 4-hydroxyphenol, p-hydroquinone, p-hydroxyphenol, p-dihydroxybenzene, benzoquinol, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, Chemical Storage and Management Resource Center, Solubility in water: 70g/L in water (20C). ADS Other properties of hydroquinone are given in Table 1. Get medical attention. 0 7 r @ &. 4]DYR@'c [Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O, trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane, C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1, C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C, 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine, CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC, 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1, O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C, [Na+].[Na+].[Na+]. 0000000731 00000 n Sodium metabisulfite has the added advantage that it does not discolor by oxidation. Continue rinsing.IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.Avoid release to the environment.WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. However, the oil-soluble TBHQ is more hydrophobic with a distinctly increased log P value compared to HQ. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. This composition is color stabilized and cosmetically elegant. Phase B: Dissolve the ferulic acid in the glycerin - some "spirited" stirring may be necessary. Pigmentation disorders can take a variety of forms like hyperpigmentation and hypopigmentation, such as melasma (dark patches experienced in pregnancy), liver spots (which often develop with age), as a side effect of birth control pills, and as a persistent result of acne, bums, bites and other skin injuries, and vitiligo.